Buffalo is a very small city located in the state of Missouri. With a population of 3,422 people and two associated neighborhoods, Buffalo is the 192nd largest community in Missouri.

Telecommuters are a relatively large percentage of the workforce: 7.90% of people work from home. While this number may seem small overall, as a fraction of the total workforce it is high relative to the nation. These workers are often telecommuters who work in knowledge-based, white-collar professions. For example, Silicon Valley has large numbers of people who telecommute. Other at-home workers may be self-employed people who operate small businesses out of their homes.

Buffalo is a small city, and as such doesn't have a public transit system that people use to get to and from their jobs every day.

The citizens of Buffalo are slightly less educated than the national average of 21.84% for the average city or town: 14.03% of adults in Buffalo have a bachelor's degree or advanced degree

The per capita income in Buffalo in 2022 was $23,205, which is lower middle income relative to Missouri, and low income relative to the rest of the US. This equates to an annual income of $92,820 for a family of four. However, Buffalo contains both very wealthy and poor people as well. Buffalo also has one of the higher rates of people living in poverty in the nation, with 41.23% of its population below the federal poverty line.

The people who call Buffalo home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of Buffalo residents report their race to be White, followed by Black or African-American. Important ancestries of people in Buffalo include English, German, Irish, Scandinavian, and Russian.

The most common language spoken in Buffalo is English. Other important languages spoken here include Spanish and Italian.