De Soto is a somewhat small city located in the state of Missouri. With a population of 6,451 people and four associated neighborhoods, De Soto is the 112th largest community in Missouri.

Telecommuters are a relatively large percentage of the workforce: 11.53% of people work from home. While this number may seem small overall, as a fraction of the total workforce it is high relative to the nation. These workers are often telecommuters who work in knowledge-based, white-collar professions. For example, Silicon Valley has large numbers of people who telecommute. Other at-home workers may be self-employed people who operate small businesses out of their homes.

In De Soto, however, the average commute to work is quite long. On average, people spend 33.47 minutes each day getting to work, which is significantly higher than the national average.

In terms of college education, the citizens of De Soto rank slightly lower than the national average. 13.41% of adults 25 and older in De Soto have a bachelor's degree or advanced degree, while 21.84% of adults have a 4-year degree or higher in the average American community.

The per capita income in De Soto in 2022 was $24,846, which is middle income relative to Missouri, and lower middle income relative to the rest of the US. This equates to an annual income of $99,384 for a family of four. However, De Soto contains both very wealthy and poor people as well.

De Soto is a somewhat ethnically-diverse city. The people who call De Soto home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of De Soto residents report their race to be White, followed by Asian. Important ancestries of people in De Soto include German, Irish, English, French, and Italian.

The most common language spoken in De Soto is English. Other important languages spoken here include Italian and Polish.