De Soto is a somewhat small city located in the state of Missouri. With a population of 6,451 people and four associated neighborhoods, De Soto is the 112th largest community in Missouri.

Telecommuters are a relatively large percentage of the workforce: 11.53% of people work from home. While this number may seem small overall, as a fraction of the total workforce it is high relative to the nation. These workers are often telecommuters who work in knowledge-based, white-collar professions. For example, Silicon Valley has large numbers of people who telecommute. Other at-home workers may be self-employed people who operate small businesses out of their homes.

One downside of living in De Soto is that it can take a long time to commute to work. In De Soto, the average commute to work is 33.47 minutes, which is quite a bit higher than the national average.

The citizens of De Soto are slightly less educated than the national average of 21.84% for the average city or town: 13.41% of adults in De Soto have a bachelor's degree or advanced degree

The per capita income in De Soto in 2022 was $24,846, which is middle income relative to Missouri, and lower middle income relative to the rest of the US. This equates to an annual income of $99,384 for a family of four. However, De Soto contains both very wealthy and poor people as well.

De Soto is a somewhat ethnically-diverse city. The people who call De Soto home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of De Soto residents report their race to be White, followed by Asian. Important ancestries of people in De Soto include German, Irish, English, French, and Italian.

The most common language spoken in De Soto is English. Other important languages spoken here include Italian and Polish.